Oral herpes simplex virus (HSV) infections cause sores to form on the mouth, lips, or gums. HSV has 2 types. Oral HSV infections are most often caused by HSV type 1. HSV type 2 normally affects the genital area, but may also occur in the mouth. After you are infected, the virus hides in your nerves and may return. An HSV infection that comes back is also known as a cold sore.
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A potent phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor; shows antiviral activity against herpes simplex virus (HSV); a novel antimicrobial agent.
Amenamevir is a potent viral helicase-primase inhibitor that possesses antiviral activity against VZV, HSV1 and HSV2 with EC50 of 0.028-0.1 uM; exerts equipotent activity against VZV, HSV-1 and HSV-2 through prevention of viral DNA replication; also shows activity against aciclovir-resistant VZV.
Valacyclovir hydrochloride is an antiviral agent that acts as a very potent inhibitor of viral DNA polymerase; a prodrug of aciclovir for management of herpes simplex (HSV), herpes zoster and herpes B infection.
Valnivudine (FV-100;FV100;CF-1743) is a potent, selective, bicyclic nucleoside analogue inhibitor of varicella zoster virus (VZV) with EC50 of subnanomolar range in vitro.
Penciclovir (VSA-671;BRL-39123) is a guanosine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections; inhibits viral DNA polymerase and exhibits low toxicity and good selectivity.
Acyclovir (Aciclovir;Acycloguanosine) is an antiviral agent that competitively inhibits and inactivates HSV-specified DNA polymerases preventing further viral DNA synthesis without affecting the normal cellular processes; primarily used for the treatment of HSV infections.
Fiacitabine (NSC-382097;FIAC) is a synthesized pyrimidine analog that is a potent and selective anti-herpesvirus agent; suppresses various strains of HSV1 and HSV2 with IC90 of 2.5 nM and 12.6 nM, respectively, shows minimal cytotoxicity; more potent than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine.
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