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    Ack1

    Ack1 (Activated CDC42 kinase 1) is an enzyme that in humans is encoded by the TNK2 gene. Ack1 binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). Ack1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. Ack1 is a survival kinase and shown to be associated with tumor cell survival, proliferation, hormone-resistance and radiation resistance. Ack1 has emerged as a new cancer target and multiple small molecule inhibitors have been reported.

    相关产品

    目录 产品名 产品简述
    GY05026 新品 (R)-9b Ack1抑制剂(R)-9b是一种有效的选择性ACK1(TNK2)抑制剂,IC50为48 nM。
    GY02615 KRCA-0008 KRCA-0008是一个高效选择性ALK/Ack1抑制剂,对ALK和Ack1的IC50值分别为12nM和4nM,具有非hERG依赖性药物特征。
    GY03634 AIM-100 AIM-100是Ack1抑制剂,IC50为24nM。
    GY05652 (R)-9bMS (R)-9bMS是一种有效的选择性ACK1(TNK2)抑制剂,IC50为48 nM。
    GY06351 Ack1 inhibitor 37 Ack1 inhibitor 37是一种有效的选择性Ack1(TNK2)抑制剂,Ki为0.3 nM,对相关激酶LCK,JAK3,KDR和TIE2(Ki=138,6.5,380和200 nM)显示出高选择性。


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