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Chemical Structure MK-571

CAS No.: 115103-85-0

MK-571(L-660711 sodium salt)

Catalog No.GY03982Research Only, Not for Human Use!

A potent and specific LTD4 receptor antagonist with Ki of 0

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Purity & Documentation Purity: >98%(HPLC) Select Batch:

Biological Activity

A potent and specific LTD4 receptor antagonist with Ki of 0.22 nM; effectively blocks LTD4 activation of recombinant human and mouse CysLT1 receptors; also is an inhibitor of multidrug resistance protein-1 (MRP1) mediated transportorally active.

Physicochemical Properties

M.Wt 537.07
Formula C26H26ClN2NaO3S2
CAS No. 115103-85-0
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month

DMSO: ≥ 33 mg/mL

Chemical Name Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-, sodium salt, (E)- (9CI)

Clinical Information

Phase 2 Clinical


1. Gauthier JY, et al. J Med Chem. 1990 Oct;33(10):2841-5.

2. Vellenga E, et al. Br J Pharmacol. 1999 May;127(2):441-8.

3. Lynch K, et al. Nature. 1999 Jun 24;399(6738):789-93.

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