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Mavacamten

Chemical Structure Mavacamten

CAS No.: 1642288-47-8

Mavacamten(SAR-439152;MYK-461)

Catalog No.GY05794Research Only, Not for Human Use!

Mavacamten (SAR-439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain

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5 mg USD 228 In stock
25 mg USD 448 In stock
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Purity & Documentation Purity: > 98%(HPLC) Select Batch:

Biological Activity

Mavacamten (SAR-439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain; inhibits α and β isoforms of cardiac myosin with similar activity (IC50=0.3 uM); suppresses the development of ventricular hypertrophy, cardiomyocyte disarray, and myocardial fibrosis and attenuates hypertrophic and profibrotic gene expression in mice harboring heterozygous human mutations in the myosin heavy chain.

Physicochemical Properties

M.Wt 273.336
Formula C15H19N3O2
CAS No. 1642288-47-8
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

10 mM in DMSO

Chemical Name (S)-3-isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione

Clinical Information

Other Indication
Phase 2 Clinical

References

1. Green EM, et al. Science. 2016 Feb 5;351(6273):617-21.

2. Stern JA, et al. PLoS One. 2016 Dec 14;11(12):e0168407.

3. Kawas RF, et al. J Biol Chem. 2017 Oct 6;292(40):16571-16577.

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