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L-779450

Chemical Structure L-779450

CAS No.: 303727-31-3

L-779450(L779450)

Catalog No.GY03146Research Only, Not for Human Use!

L-779450 is a potent, ATP-competitive Raf kinase inhibitor with IC50 of 10 nM, displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively

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Purity & Documentation Purity: > 98%(HPLC) Select Batch:

Biological Activity

L-779450 is a potent, ATP-competitive Raf kinase inhibitor with IC50 of 10 nM, displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively; suppresses DNA synthesis and induced apoptosis in hematopoietic FDC-P1 cells transformed to grow in response to either Raf-1 or A-Raf, L-779,450 is less effective on B-Raf- or MEK1-responsive cells, also suppresses DNA synthesis and induces apoptosis in Raf-responsive cells and the effects are more significant on Raf-responsive compared to cytokine-mediated growth.

Physicochemical Properties

M.Wt 347.8
Formula C20H14ClN3O
CAS No. 303727-31-3
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

DMSO: ≥ 34 mg/mL

Chemical Name Phenol, 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]-

Clinical Information


References

1. Shelton JG, et al. Leukemia. 2003 Sep;17(9):1765-82.

2. Takle AK, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6.

3. McKay MM, et al. Curr Biol. 2011 Apr 12;21(7):563-8.

4. Berger A, et al. J Invest Dermatol. 2014 Feb;134(2):430-440.

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