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You are here:Home-Inhibitors & Agonists-Proteasome/Ubiquitin-Deubiquitinase (DUB)-FT-671
FT-671

Chemical Structure FT-671

CAS No.: 1959551-26-8

FT-671(FT671;FT 671)

Catalog No.GY07086Research Only, Not for Human Use!

FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain)

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Purity & Documentation Purity: 98%(HPLC) Select Batch:

Biological Activity

FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain); inhibits USP7 with IC50 values of 52 nM (USP7 CD) and 69 nM (USP7C-term), display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs); destabilizes USP7 substrates including MDM2, increases levels of p53, and results in the transcription of p53 target genes and induces tumour suppressor p21; blocks the proliferation of MM.1S cells (IC50=33 nM), suppresses tumour growth in mice; orally available.

Physicochemical Properties

M.Wt 533.488
Formula C24H23F4N7O3
CAS No. 1959551-26-8
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
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Solubility

Chemical Name (S)-5-((1-(4,4-difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Clinical Information


References

1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.

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