Chemical Structure YZ129
CAS No.: 1643120-60-8
Catalog No.: GY10414Research Only, Not for Human Use!
YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM
|100 mg||Get quote|
|250 mg||Get quote|
|500 mg||Get quote|
|1 g||Get quote|
Tech Support: email@example.com
YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM; also suppressed the expression of NFAT-regulated genes, such as COX2, MMP7, and MMP9, in U87 GBM cells; directly binds to HSP90 to antagonize its chaperoning effect on calcineurin, a Ca2+-sensitive phosphatase that is required for NFAT nuclear translocation and subsequent gene expression; YZ129 could not only suppress cancer cell growth but also reduce cancer cell movement and migration of of GBM cells in vitro; suppresses the growth of GBM xenografts in vivo.
1. Liu Z, et al. Cell Chem Biol. 2018 Nov 30. pii: S2451-9456(18)30431-8.
No.1378 West Wenyi Road, Yuhang District, HangZhou, Zhejiang, China