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You are here:Home-Inhibitors & Agonists-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-YZ129
YZ129

Chemical Structure YZ129

CAS No.: 1643120-60-8

YZ129(YZ-129;YZ 129)

Catalog No.GY10414Research Only, Not for Human Use!

YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM

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Biological Activity

YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM; also suppressed the expression of NFAT-regulated genes, such as COX2, MMP7, and MMP9, in U87 GBM cells; directly binds to HSP90 to antagonize its chaperoning effect on calcineurin, a Ca2+-sensitive phosphatase that is required for NFAT nuclear translocation and subsequent gene expression; YZ129 could not only suppress cancer cell growth but also reduce cancer cell movement and migration of of GBM cells in vitro; suppresses the growth of GBM xenografts in vivo.

Physicochemical Properties

M.Wt 300.317
Formula C19H12N2O2
CAS No. 1643120-60-8
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

4-(isoquinolin-6-ylamino)naphthalene-1,2-dione

Clinical Information


References

1. Liu Z, et al. Cell Chem Biol. 2018 Nov 30. pii: S2451-9456(18)30431-8.

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