TAS-117 hydrochloride | RayStarBio.com

Chemical Structure TAS-117 hydrochloride

CAS No.:

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TAS-117 hydrochloride(TAS117)

Catalog No.: GY05576Research Only, Not for Human Use!

TAS-117 hydrochloride (TAS117) is a potent, selective, allosteric inhibitor of Akt with IC50 of 4

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Biological Activity

TAS-117 hydrochloride (TAS117) is a potent, selective, allosteric inhibitor of Akt with IC50 of 4.8/1.6/44 for Akt1/2/3, respectively; displays no or only minimal inhibitory activities against other protein and lipid kinases, including PI3K, PDK1, and mTOR at 1 uM; inhibits Akt kinase activity but not p-Akt; induces significant growth inhibition, associated with downregulation of p-Akt, selectively in MM cell lines with high baseline p-Akt; significantly inhibits human MM cell growth in murine xenograft models, orally active

Physicochemical Properties

M.Wt	460.962
Formula	C₂₆H₂₅ClN₄O₂
CAS No.
Storage	Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 3 Month
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Solubility
Chemical Name	Trans-3-amino-1methyl-3-[4-(3-phenyl-5H- imidazo[1,2-c]pyrido[3,4-e][1,3]oxazin-2-yl)phenyl]-cyclobutanol hydrochloride

Clinical Information

Solid Tumors
Phase 2 Clinical

References

1. Mimura N, et al. Cancer Res. 2014 Aug 15;74(16):4458-69.

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