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RU-521

Chemical Structure RU-521

CAS No.: 2262452-06-0

RU-521(RU.521;RU521;RU-320521 )

Catalog No.GY05580Research Only, Not for Human Use!

RU-521 (RU

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25 mg USD 488 In stock
100 mg USD 1280 In stock
250 mg Get quote
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Purity & Documentation Purity: > 98%(HPLC) Select Batch:

Biological Activity

RU-521 (RU.521, RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM; inhibits cGAS-mediated interferon upregulation in cellular assays, with no effect on inflammatory pathways independent of cGAS; suppresses the chronically elevated levels of type I interferon in primary macrophages from mice model of AGS (Aicardi-Goutières syndrome).

Physicochemical Properties

M.Wt 415.23
Formula C19H12Cl2N4O3
CAS No. 2262452-06-0
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name 3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one

Clinical Information


References

1. Vincent J, et al. Nat Commun. 2017 Sep 29;8(1):750.

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