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PF-6808472

Chemical Structure PF-6808472

CAS No.: 2088112-70-1

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PF-6808472(XO44)

Catalog No.: GY05462Research Only, Not for Human Use!

PF-6808472 (XO44) is a sulfonyl fluoride chemical probe that covalently labels a broad swath of the intracellular kinome with high efficiency

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Purity & Documentation Purity: > 98%(HPLC) Select Batch:

Biological Activity

PF-6808472 (XO44) is a sulfonyl fluoride chemical probe that covalently labels a broad swath of the intracellular kinome with high efficiency; covalently modifies up to 133 endogenous kinases, efficiently competes with high intracellular concentrations of ATP; an useful tool in demanding chemoproteomic applications.

Physicochemical Properties

M.Wt 538.602
Formula C25H27FN8O3S
CAS No. 2088112-70-1
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
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Solubility

Chemical Name 4-{4-[4-(5-Cyclopropyl-1H-pyrazol-3-ylamino)-6-prop-2-ynylcarbamoyl-pyrimidin-2-yl]-piperazin-1-ylmethyl}-benzenesulfonyl fluoride

Clinical Information


References

1. Zhao Q, et al. J Am Chem Soc. 2017 Jan 18;139(2):680-685.

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