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You are here:Home-Inhibitors & Agonists-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-KNK-437
KNK-437

Chemical Structure KNK-437

CAS No.: 218924-25-5

KNK-437(KNK437)

Catalog No.GY01899Research Only, Not for Human Use!

An inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells

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Biological Activity

An inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells; inhibits the acquisition of thermotolerance as developed by sodium arsenite, also inhibited at mRNA levels; shows no antitumor effects and does not increase the thermosensitivity of nontolerant tumors in vivo (up to 200 mg/kg).

Physicochemical Properties

M.Wt 245.23
Formula C13H11NO4
CAS No. 218924-25-5
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name 1-Pyrrolidinecarboxaldehyde, 3-(1,3-benzodioxol-5-ylmethylene)-2-oxo-

Clinical Information

Colon Cancer
Preclinical

References

1. Yokota S, et al. Cancer Res. 2000 Jun 1;60(11):2942-8.

2. Koishi M, et al. Clin Cancer Res. 2001 Jan;7(1):215-9.

3. Guo F, et al. Cancer Res. 2005 Nov 15;65(22):10536-44.

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