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KNI-1657

Chemical Structure KNI-1657

CAS No.: 2236594-14-0

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KNI-1657(KNI1657)

Catalog No.: GY05600Research Only, Not for Human Use!

KNI-1657 (KNI1657) is a highly potent HIV-1 protease inhibitor (97% inhibition at 1 nM) with high sensitivity against lopinavir/ritonavir- or darunavir-resistant strains

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Purity & Documentation Purity: > 98%(HPLC) Select Batch:

Biological Activity

KNI-1657 (KNI1657) is a highly potent HIV-1 protease inhibitor (97% inhibition at 1 nM) with high sensitivity against lopinavir/ritonavir- or darunavir-resistant strains; inhibits wild-type HIV-1 (pNL4-3) and LPV-resistant strain A17 with IC50 of <3 and 25 nM, respectively.

Physicochemical Properties

M.Wt 756.915
Formula C41H48N4O8S
CAS No. 2236594-14-0
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
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Solubility

Chemical Name (R)-N-(2,6-dimethylbenzyl)-3-((2S,3S)-2-hydroxy-3-((S)-2-(7-methoxybenzofuran-2-carboxamido)-2-((R)-tetrahydrofuran-3-yl)acetamido)-4-phenylbutanoyl)-5,5-dimethylthiazolidine-4-carboxamide

Clinical Information


References

1. Hidaka K, et al. J Med Chem. 2018 May 31. doi: 10.1021/acs.jmedchem.7b01709.

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