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You are here:Home-Inhibitors & Agonists-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-JG-231

Chemical Structure JG-231

CAS No.: 1627126-59-3


Catalog No.GY06808Research Only, Not for Human Use!

JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0

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Purity & Documentation Purity: 98%(HPLC) Select Batch:

Biological Activity

JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively; reduces tumor burden in an MDA-MB-231 xenograft model (4 mg/kg, ip).

Physicochemical Properties

M.Wt 619.45
Formula C22H18BrCl2N3OS4
CAS No. 1627126-59-3
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month

Chemical Name 3-((5-bromothiophen-2-yl)methyl)-2-((Z)-((E)-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4-oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride

Clinical Information


1. Shao H, et al. J Med Chem. 2018 Jul 13. doi: 10.1021/acs.jmedchem.8b00583.

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