IACS-010759 |1570496-34-2 RayStarBio.com

Chemical Structure IACS-010759

CAS No.: 1570496-34-2

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IACS-010759(IACS010759)

Catalog No.: GY05498Research Only, Not for Human Use!

IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain

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5 mg	USD 118	In stock
25 mg	USD 368	In stock
100 mg	USD 688	In stock
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Biological Activity

IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain; decreases cell viability and increases apoptosis with EC50 values between 1 nM-50 nM across multiple lines; robustly inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, reduces aspartate production that leads to impaired nucleotide biosynthesis; potently inhibits tumor growth of brain cancer and AML in vivo.

Physicochemical Properties

M.Wt	562.568
Formula	C₂₅H₂₅F₃N₆O₄S
CAS No.	1570496-34-2
Storage	Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 3 Month
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Solubility
Chemical Name	5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Clinical Information

Blood Cancer
Phase 1 Clinical

References

1. Molina JR, et al. Nat Med. 2018 Jun 11. doi: 10.1038/s41591-018-0052-4.

2. Vangapandu HV, et al. Oncotarget. 2018 May 18;9(38):24980-24991.

3. Lissanu Deribe Y, et al. Nat Med. 2018 Jun 8. doi: 10.1038/s41591-018-0019-5.

4. Jennifer Molina, et al. Abstract 4971: IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors. AACR. DOI: 10.1158/1538-7445.

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