Welcome to Raystarbio!Focus On Forefront Bioactive Compounds.
Find Your Distributors

Select Your Country or Region

$ USD

You are here:Home-Inhibitors & Agonists-Proteasome/Ubiquitin-Ubiquitin-conjugating Enzyme (E2)-DI-591
DI-591

Chemical Structure DI-591

CAS No.: 2245887-38-9

DI-591(DI591)

Catalog No.GY05610Research Only, Not for Human Use!

DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2

Packing Price Stock Quantity
100 mg Get quote
250 mg Get quote
1 g Get quote

E-mail: sales@raystarbio.com

Tech Support: services@raystarbio.com

Purity & Documentation Purity: > 98%(HPLC) Select Batch:

Biological Activity

DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2; displays no affinity against DCN3/4/5 (Ki>10 uM); selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members; accumulates NRF2 protein and its transcriptional activation in cells.

Physicochemical Properties

M.Wt 585.808
Formula C31H47N5O4S
CAS No. 2245887-38-9
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name (S)-N-((S)-1-cyclohexyl-2-(3-morpholinopropanamido)ethyl)-3-(6-isopropylbenzo[d]thiazol-2-yl)-2-propionamidopropanamide

Clinical Information


References

1. Zhou H, et al. Nat Commun. 2017 Oct 27;8(1):1150.

View Related Products by Target

© Copyright 2020 RayStarBio. All Rights Reserved. Products are only for research use

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: