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You are here:Home-Inhibitors & Agonists-Others-Other Targets-CCG-203586
CCG-203586

Chemical Structure CCG-203586

CAS No.: 1430611-24-7

CCG-203586(CCG203586)

Catalog No.GY05511Research Only, Not for Human Use!

CCG-203586 (CCG203586) is a potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM

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Purity & Documentation Purity: > 98%(HPLC) Select Batch:

Biological Activity

CCG-203586 (CCG203586) is a potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM; inhibits GlcCer production in whole wild-type MDCKII cells with IC50 of 15.3 nM, has little to no apparent recognition by MDR1; significantly and dose-dependently decreases brain glucosylceramide content after intraperitoneal administration in mice.

Physicochemical Properties

M.Wt 436.552
Formula C26H32N2O4
CAS No. 1430611-24-7
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
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Solubility

Chemical Name 2-(2,3-dihydro-1H-inden-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)acetamide

Clinical Information


References

1. Larsen SD, et al. J Lipid Res. 2012 Feb;53(2):282-91.

2. Arthur JR, et al. Neurochem Res. 2013 Apr;38(4):866-75.

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