BAY-885 |2307249-33-6 RayStarBio.com

Chemical Structure BAY-885

CAS No.: 2307249-33-6

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BAY-885(BAY885)

Catalog No.: GY05624Research Only, Not for Human Use!

BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM, shows high selectivity over a panel of 357 kinases (Eurofins panel)

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Biological Activity

BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM, shows high selectivity over a panel of 357 kinases (Eurofins panel); strongly inhibits EGF-stimulated MEF2 transcriptional activity in MEF2 reporter assay with IC50 of 115 nM; despite its high potency, BAY-885 failed to inhibit the proliferation of cells with ERK5 genomic amplification (SN12C, SNU-449, MFM-223) or with constitutively active ERK5 signaling (BT-474, SK-BR-3).

Physicochemical Properties

M.Wt	515.541
Formula	C₂₅H₂₈F₃N₇O₂
CAS No.	2307249-33-6
Storage	Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 3 Month
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Solubility
Chemical Name	(2-amino-4-(trifluoromethoxy)phenyl)(4-(7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl)piperidin-1-yl)methanone

Clinical Information

References

1. Clara Lemos, et al. Abstract 5866: Discovery and profiling of a highly potent and selective ERK5 inhibitor: BAY-885. AACR. 2018.

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