Welcome to Raystarbio!Focus On Forefront Bioactive Compounds.
Find Your Distributors

Select Your Country or Region

$ USD

You are here:Home-Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-ERK-BAY-885
BAY-885

Chemical Structure BAY-885

CAS No.: 2307249-33-6

BAY-885(BAY885)

Catalog No.GY05624Research Only, Not for Human Use!

BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM, shows high selectivity over a panel of 357 kinases (Eurofins panel)

Packing Price Stock Quantity
100 mg Get quote
250 mg Get quote
1 g Get quote

E-mail: sales@raystarbio.com

Tech Support: services@raystarbio.com

Purity & Documentation Purity: > 98%(HPLC) Select Batch:

Biological Activity

BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM, shows high selectivity over a panel of 357 kinases (Eurofins panel); strongly inhibits EGF-stimulated MEF2 transcriptional activity in MEF2 reporter assay with IC50 of 115 nM; despite its high potency, BAY-885 failed to inhibit the proliferation of cells with ERK5 genomic amplification (SN12C, SNU-449, MFM-223) or with constitutively active ERK5 signaling (BT-474, SK-BR-3).

Physicochemical Properties

M.Wt 515.541
Formula C25H28F3N7O2
CAS No. 2307249-33-6
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name (2-amino-4-(trifluoromethoxy)phenyl)(4-(7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl)piperidin-1-yl)methanone

Clinical Information


References

1. Clara Lemos, et al. Abstract 5866: Discovery and profiling of a highly potent and selective ERK5 inhibitor: BAY-885. AACR. 2018.

View Related Products by Target

ERK
© Copyright 2020 RayStarBio. All Rights Reserved. Products are only for research use

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: