Welcome to Raystarbio!Focus On Forefront Bioactive Compounds.
Find Your Distributors

Select Your Country or Region

$ USD

You are here:Home-Inhibitors & Agonists-Proteasome/Ubiquitin-Ubiquitin-conjugating Enzyme (E2)

Request The Product List ofUbiquitin-conjugating Enzyme (E2) Ubiquitin-conjugating Enzyme (E2)

Cat. No. Product Name CAS No. Information
GY10102

NSC697923

343351-67-7

NSC697923 (NSC 697923) is a small molecule that specifically inhibits the activity of the ubiquitin-conjugating (E2) enzyme Ubc13 (UBE2N)-Uev1A; NSC697923 impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-κB activity in ABC-DLBCL cells, inhibits NF-κB activation induced by PMA, but not by TNFα; specifically inhibits Ubc13-mediated polyubiquitin chain synthesis in vitro, does not inhibits UbcH5c-mediated polyubiquitin chain formation; inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells.

GY10526

WS-383 hydrochloride

2247544-02-9

WS-383 hydrochloride (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM; inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27 and NRF2; exhibits cellular target engagement to DCN1 in MGC-803 cells, enhances the thermal stability of cellular DCN1 protein even at 1 uM

GY10527

WS-383

2247543-65-1

WS-383 (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM; inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27 and NRF2; exhibits cellular target engagement to DCN1 in MGC-803 cells, enhances the thermal stability of cellular DCN1 protein even at 1 uM

GY02056

TZ9

1002789-86-7

A novel selective inhibitor of Rad6 ubiquitin conjugating enzyme; inhibits Rad6B-ubiquitin thioester formation and subsequent ubiquitin transfer to histone H2A, with no activity for UbcH5; potently inhibits proliferation, colony formation, and migration and induces MDA-MB-231 breast cancer cell G2-M arrest and apoptosis.

GY06324

C25-140

1358099-18-9

C25-140(TRAF6-Ubc13 inhibitor C25-140) is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity; C25-140 effectively reduced TRAF6-mediated ubiquitin chain formation in vitro, impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells; does not effect other E3 ligases (MDM2, TRIM63, ITCH, E6AP and RNF4), also does inhibit E1/E2 reactions.

GY06303

GSK145A

1609945-27-8

GSK145A(GSK 145A;GSK-145A) is a small molecule inhibitor of SUMO-conjugating enzyme E2 with IC50 of 12.5 uM, GSK145A is competitive with the sumoylation of the TRPS1 peptide substrates.

GY06272

UBE2M-DCN1 inhibitor 52

2089293-14-9

UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM, inhibits cullin neddylation in pulse-chase NEDD8 transfer assay with EC50 of 80 nM; binds to DCN1 and selectively reduce steady-state levels of neddylated CUL1 and CUL3 in a squamous cell carcinoma cell line, inhibits DCN1 but not DCN3 stimulated NEDD8 transfer from UBE2F to the cullin

GY06271

NAcM-OPT

2089293-61-6

NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays; also inhibits DCN2, but has no activity against DCN3, DCN4, or DCN5; inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.

GY06270

NAcM-COV

2089293-81-0

NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays; shows highly selectivity with respect to other protein acetyl-amide-binding sites; inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.

GY05611

DI-404

2187412-79-7

DI-404 is a highly potent, peptidomimetic inhibitor of DCN1-UBC12 protein-protein interaction that bind to DCN1 protein with Kd of 6.9 nM, selectively inhibits the neddylation of cullin 3 over other cullin members; effectively enhances the thermal stability of cellular DCN1 protein at 0.3 uM in H2170 cells, decreases the association of cellular DCN1 protein with cellular UBC12 protein in a dose-dependent manner; effectively increases the level of NRF2 protein, a substrate of cullin 3 CRL (CRL3), but has no effect on CDT1, a substrate of cullin 4A CRL (CRL4A)

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:
© Copyright 2020 RayStarBio. All Rights Reserved. Products are only for research use