Sexual function is a complex physiological process. The maintenance of normal sexual function depends on the cooperation of multiple systems of human body, which involves the coordination of nervous system, cardiovascular system, endocrine system and reproductive system. In addition, it must have good mental state and healthy psychology. When the above system or mental and psychological aspects have abnormal changes, it will affect the normal sexual life, affect the quality of sexual life, and show sexual dysfunction.
Sexual dysfunction is the disorder of sexual behavior and sexual sensation, which is often manifested as the abnormality or absence of sexual psychological and physiological response, and it is the general term of many different symptoms. According to statistics, 52% of men aged 40-70 have different degrees of sexual dysfunction. The incidence rate of female sexual dysfunction is also high. Some people think that it can account for 30% to 60% of adult women. Sexual desire and orgasm disorders are most common among them. Some women may never have orgasms in their lifetime.
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Enclomiphene citrate((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476) is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism; inhibits the ER in the pituitary gland, reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, increases gonadotropin secretion and hence gonadal production of testosterone.
PF-00446687 (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM; displays >100-fold selectivity over MC1R/1 uM); is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.
PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM; displays >100-fold selectivity over MC1R/1 uM); is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.
PF592379 is a potent, selective, orally active agonist of dopamine D3 receptor with EC50 of 21 nM; displays >470 and 180-fold functional selectivity over D2 and D4 dopamine receptors, respectively; demonstrates activity in animal models of male erectile dysfunction.
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