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Request The Product List ofMigraine Migraine

   Migraine can cause severe throbbing pain or a pulsing sensation, usually on one side of the head. It's often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. Migraine attacks can last for hours to days, and the pain can be so severe that it interferes with your daily activities.


多发性硬化图

    For some people, a warning symptom known as an aura occurs before or with the headache. An aura can include visual disturbances, such as flashes of light or blind spots, or other disturbances, such as tingling on one side of the face or in an arm or leg and difficulty speaking.


    Medications can help prevent some migraines and make them less painful. The right medicines, combined with self-help remedies and lifestyle changes, might help.

Cat. No. Product Name CAS No. Information
GY10474

BGC20-1531

1962928-26-2

BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7.6-7.8); shows no appreciable affinity at a wide range of other receptors (including other prostanoid receptors), channels, transporters and enzymes (pKi < 5); competitively antagonizes PGE(2)-induced vasodilatation of human middle cerebral (pK(B) 7.8) and meningeal (pK(B) 7.6) arteries in vitro, and PGE(2)-induced increase in canine carotid blood flow in vivo.

GY06634

Ubrogepant

1374248-77-7

Ubrogepant (MK-1602) is a novel potent, selective, oral calcitonin gene-related peptide receptor (CGRP) antagonist for acute treatment of migraine.

GY06633

Atogepant

1374248-81-3

Atogepant is a potent, selective and orally available CGRP receptor antagonist for the prevention of migraine.

GY06631

MK-8825

1380887-60-4

MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP; blocks hCGRP-stimulated cAMP responses in HEK293 cells stably expressing the human CGRP receptor with IC50 of 0.23 nM; possesses significantly improved in vivo potency in rat pharmacodynamic models.

GY04015

Eletriptan hydrobromide

177834-92-3

Eletriptan (UK 116044) is a potent, selective, and orally active 5-HT1B/1D receptor agonist; significantly increases occluded wedge pressure and mean pulmonary artery pressure in vivo, with no significant coronary artery constriction, and obstructive coronary artery disease; displays antimigraine activity.

GY03772

Valproic acid

99-66-1

A HDAC inhibitor that selectively inhibits the catalytic activity of class I HDACs, and induces proteasomal degradation of HDAC2; induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from AML patients; reduces tumor growth and metastasis formation in animal model.

GY05290

AMG-333

1416799-28-4

AMG-333 (AMG333, AMG 333) is a novel potent, highly selective TRPM8 antagonist with IC50 of 13 nM and 20 nM for hTRPM8 and rTRPM8, respectively; displays high selectivity over other TRP channels (IC50>20 uM, TRPV1/V3/V4/A1); exhibits statistically significant and dose-dependent prevention of icilin-induced rat WDS, at 0.6, 1 and 3 mg/kg, inhibits cold-induced increase in blood pressure in the rat CPT in a dose-dependent manner with 1 and 3 mg/kg producing significant inhibition with an ED90 of 1.1 mg/kg, also fully blocks the cold pressor response at 3 mg/kg.

GY05137

Dasolampanel

503294-13-1

Dasolampanel (NGX426) is an orally bioavailable, competitive antagonist of the AMPA-kainate receptors for the treatment of chronic pain conditions including neuropathic pain and migraine.

GY05035

Frovatriptan

158930-17-7

A potent, long lasting 5-HT(1B/1D) receptor agonist as a antimigraine agent.

GY05034

Eletriptan

143322-58-1

Eletriptan (UK 116044) is a potent, selective, and orally active 5-HT1B/1D receptor agonist; significantly increases occluded wedge pressure and mean pulmonary artery pressure in vivo, with no significant coronary artery constriction, and obstructive coronary artery disease; displays antimigraine activity.

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