HSV (Herpes simplex virus) can be spread when an infected person is producing and shedding the virus. Herpes simplex can be spread through contact with saliva, such as sharing drinks. Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. Lesions heal with ascab characteristic of herpetic disease.
As neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons. After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks.
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Amenamevir is a potent viral helicase-primase inhibitor that possesses antiviral activity against VZV, HSV1 and HSV2 with EC50 of 0.028-0.1 uM; exerts equipotent activity against VZV, HSV-1 and HSV-2 through prevention of viral DNA replication; also shows activity against aciclovir-resistant VZV.
Valacyclovir is an antiviral agent that acts as a very potent inhibitor of viral DNA polymerase; a prodrug of aciclovir for management of herpes simplex (HSV), herpes zoster and herpes B infection.
Valacyclovir hydrochloride is an antiviral agent that acts as a very potent inhibitor of viral DNA polymerase; a prodrug of aciclovir for management of herpes simplex (HSV), herpes zoster and herpes B infection.
Valnivudine (FV-100;FV100;CF-1743) is a potent, selective, bicyclic nucleoside analogue inhibitor of varicella zoster virus (VZV) with EC50 of subnanomolar range in vitro.
Penciclovir (VSA-671;BRL-39123) is a guanosine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections; inhibits viral DNA polymerase and exhibits low toxicity and good selectivity.
Acyclovir (Aciclovir;Acycloguanosine) is an antiviral agent that competitively inhibits and inactivates HSV-specified DNA polymerases preventing further viral DNA synthesis without affecting the normal cellular processes; primarily used for the treatment of HSV infections.
Fiacitabine (NSC-382097;FIAC) is a synthesized pyrimidine analog that is a potent and selective anti-herpesvirus agent; suppresses various strains of HSV1 and HSV2 with IC90 of 2.5 nM and 12.6 nM, respectively, shows minimal cytotoxicity; more potent than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine.
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