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    Gout is a type of arthritis. It occurs when uric acid builds up in blood and causes inflammation in the joints.

    Acute gout is a painful condition that often affects only one joint. Chronic gout is the repeated episodes of pain and inflammation. More than one joint may be affected.


   Gout is caused by having higher-than-normal level of uric acid in your body. This may occur if:

 ~Your body makes too much uric acid

 ~Your body has a hard time getting rid of uric acid

Illustration of a leukocyte in a blood vessel, showing it attach to the inside of the vessel wall through rolling adhesion, then tight adhesion. The leukocyte squeezes through the blood vessel wall, which is called extravasation, to get into the tissue to the site of inflammation, bacteria, or injury.

     When uric acid builds up in the fluid around the joints (synovial fluid), uric acid crystals form. These crystals cause the joint to become inflamed, causing pain, swelling and warmth.

     The exact cause is unknown. Gout may run in families. The problem is more common in men, in women after menopause, and people who drink alcohol. As people become older, gout becomes more common.

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A highly potent and specific URAT1 inhibitor with IC50 of 25 nM; displays 200-fold lower affinity for the related URAT1 homologs OAT4 and OAT1; reduces the sUA by up to 60% with a single 40 mg dose in healthy human volunteers, and increases the FEUA in a dose-dependent manner with EC50 of 22 nM; currently in phase 2 trials for the treatment of gout and asymptomatic hyperuricemia.

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