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You are here:Home-Inhibitors & Agonists-Cytoskeleton/Cell Adhesion Molecules-Gap Junction Protein

Request The Product List ofGap Junction Protein Gap Junction Protein

Gap junction channels are essential in normal heart function and they assist in the mediated spread of electrical impulses that stimulate synchronized contraction (via an electrical syncytium) of cardiac tissues.

Gap junction (GJ) proteins play an important role in direct communication between cells of many tissue types. GJs are specialised intercellular membrane-spanning domains that allow the passage of small molecules including second messenger (e.g. c-AMP, inositol triphosphate) or ionic signals from one cell to another. GJ proteins and their long evolutionary history have permitted adaptation of gap junction intercellular communication (GJIC) with several important functions and multiple regulatory processes. Formation of GJIC is an essential mechanism in coordinating growth and development and tissue compartmentalization during embryonic development.

Cat. No. Product Name CAS No. Information
GY06454

Danegaptide Hydrochloride

943133-81-1

Danegaptide Hydrochloride is a potent, orally active gap-junction modifier; prevents significantly conduction velocity slowing at 10 nM compared with vehicle; has highly desirable in vitro and in vivo safety profile including (1) lack of direct effects on membrane ion currents, hERG inhibition, and CYP450 liabilities, (2) negative AMES result, (3) a benign NovaScreen profile, and (4) no effects on systemic hemodynamics.

GY06453

Danegaptide

943134-39-2

Danegaptide is a potent, orally active gap-junction modifier; prevents significantly conduction velocity slowing at 10 nM compared with vehicle; has highly desirable in vitro and in vivo safety profile including (1) lack of direct effects on membrane ion currents, hERG inhibition, and CYP450 liabilities, (2) negative AMES result, (3) a benign NovaScreen profile, and (4) no effects on systemic hemodynamics.

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