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You are here:Home-Inhibitors & Agonists-Others-GRK (GPCRK)

Request The Product List ofGRK (GPCRK) GRK (GPCRK)

Cat. No. Product Name CAS No. Information
GY03917

GSK180736A

817194-38-0

A highly selective and potent GRK2 inhibitor with IC50 of 0.77 uM; displays >400-fold selective for GRK2 over both GRK1 and GRK5, with no inhibition on PKA; also inhibits ROCK with IC50 of 0.1 uM.

GY02860

CCG-215022

1813527-81-9

CCG-215022 (CCG215022) is a potent and selective pan GRK (G protein-coupled receptor kinase) inhibitor with IC50 of 0.15/0.38/3.9 uM for GRK2/5/1 respectively; displays 300-800 fold selectivity against PKA; exhibits improved potency compared with GSK180736A.

GY05641

CCG 258748

2410997-49-6

CCG 258748 (CCG258748;CCG-258748) is a potent, selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 8 nM; displays 30-fold selectivity over GRK5, and no significant inhibitory activity against GRK1, PKA and ROCK1.

GY05476

GRK2-IN-115h hydrochloride

1941168-71-3

A highly potent and selective GRK2 inhibitor with IC50 of 18 nM; showes enough selectivity against GRK1/5/6/7, ROCK2 and PKCα with equipotent inhibition to GRK3 (IC50=5.4 nM); potentiates βAR-mediated cAMP accumulation and prevents internalization of βARs in β2AR-expressing HEK293 cells treated with isoproterenol; a novel potential agent for heart failure treatment.

GY05465

CCG 224061

2055990-82-2

CCG 224061 (CCG224061;CCG-224061) is a potent, relatively selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 66 nM; displays >30-fold selectivity over GRK5, GRK1, PKA and ROCK1.

GY05464

CCG 258001

2055990-96-8

CCG 258001 (CCG258001;CCG-258001) is a potent, relatively selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 280 nM; displays >100-fold selectivity over GRK5, GRK1, PKA and ROCK1.

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