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You are here:Home-Inhibitors & Agonists-Antibiotics and Antivirals-Filovirus

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Filoviruses is amongst the most lethal of primate pathogens. Filoviruses cause lethal hemorrhagic fever in humans and nonhuman primates. The family Filoviridae includes two genera: Marburgvirus, comprising various strains of the Lake Victoria marburgvirus (MARV); and Ebolavirus (EBOVs), comprising four species including Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Ivory Coast ebolavirus (CIEBOV), and Reston ebolavirus (REBOV); and a tentative species Bundibugyo ebolavirus (BEBOV).


The infections typically affect multiple organs in the body and are often accompanied by hemorrhage (bleeding). Once the virus has been transmitted from an animal host to a human, it can then spread through person-to-person contact.

Cat. No. Product Name CAS No. Information
GY10363

JBJ-01-162-04

2313524-77-3

JBJ-01-162-04 is a small molecule targeting the flavivirus E protein with broad-spectrum activity, shows activity against DENV in the infectivity assay with IC90 of 0.1 uM; binds to DENV2 E protein (sE2) with Kd of 1.4 uM, reduces DENV viral burden in vivo.

GY06706

JBJ-16-111

JBJ-16-111 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E.

GY06705

Compound 3-110-22

2244892-95-1

Compound 3-110-22 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E; inhibits ZIKV PF13-251013-18 with IC90 of 4.0 uM, interacts with recombinant, soluble ZIKV E (ZIKV sE) in biolayer interferometry experiments with a KD of 2.1 uM; inhibits other flavivirus pathogens, inhibits DENV fusion by targeting E; also inhibits West Nile reporter virus with IC50 of 2.9 uM.

GY06582

GS-5734

1809249-37-3

GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays; suppresses EBOV replication and protects 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers.

GY06534

BCX-4430

222631-44-9

A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator; exhibits broad-spectrum antiviral activity against negative-sense RNA viruses representing the Filoviridae, Arenaviridae, Bunyaviridae,Orthomyxoviridae,Picornaviridae and Paramyxoviridae families, and positive-sense RNA viruses of the Flaviviridae and Coronaviridae families (EC50=5-60 uM).

GY06529

Galidesivir

249503-25-1

Galidesivir is a viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator; exhibits broad-spectrum antiviral activity against negative-sense RNA viruses representing the Filoviridae, Arenaviridae, Bunyaviridae,Orthomyxoviridae,Picornaviridae and Paramyxoviridae families, and positive-sense RNA viruses of the Flaviviridae and Coronaviridae families (EC50=5-60 uM).

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