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Request The Product List ofEnterovirus Enterovirus

Enteroviruses are members of the picornavirus family, a large and diverse group of small RNA viruses. According to the present classification, the enterovirus genus comprises the following species: poliovirus, human enterovirus A (HEV-A) (coxackie A viruses and enterovirus 71), HEV-B (coxsackie B viruses, echoviruses, coxsackie A9 virus, and enteroviruses 69 and 73), HEV-C (coxsackie A viruses), HEV-D (enteroviruses 68 and 70), and at least three animal enterovirus species (bovine, simian, and porcine enteroviruses). They all contain a genome of approximately 7,500 bases and positive [(+)]-strand polarity. After infection of the host cell, the genome is translated in a cap-independent manner into a single polyprotein, which is subsequently processed by virus-encoded proteases into the structural capsid proteins and the nonstructural proteins, which are mainly involved in the replication of the virus.

Cat. No. Product Name CAS No. Information

Pirlindole Mesylate


Pirlindole is a novel potent inhibitor of Enteroviruse that targets Viral Protein 2C, inhibits EV-B and EV-D through the inhibition of genome replication (CV-B3 EC50=9.91 uM).




ICA135 (ICA-135, ICA 135) is a broad-spectrum inhibitor against human enteroviruses that inhibits Coxsackievirus A10 (CV-A10) replication in RD cells with IC50 of 1.446 uM; exerts protective function in vivo in an established mouse model of CV-A10; exhibited inhibitory effect on Enteroviruses four species A-D with IC50 of 0.566 and 9.68 uM, including EV-A71 and CV-A16 from specie A, CV-B3 from specie B, PV-1 from specie C, and EV-D68 from specie D; bind to the VP1 hydrophobic pockets with high-binding affinity.




BF738735(BF 738735;BF-738735) is a novel, broad-spectrum inhibitor of enterovirus replication (EC50=4-71 nM) that specifically targets host cell factor PI4KIIIβ with IC50 of 5.7 nM, 300-fold less potent for PI4KIIIα (IC50=1.7 uM); blocks viral RNA replication with IC50 of 77 nM in luciferase assays, strongly inhibits CVB3 and EV71 replicon replication at 1-5 uM; reduces the PI4P levels at the Golgi complex through a direct inhibition of PI4KIIIβ activity.




SG85(SG 85) is a potent Enterovirus 3C protease inhibitor with EC50 of 180 nM against EV71 and 60 nM against human rhinovirus 14 in a live virus-cell-based assay; effectively inhibits the in vitro replication of 14 rhinoviruses representative of species A and B with mean EC50 of 40 nM, efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir.




TBZE-029(TBZE029) is a selective inhibitor of the replication of several Enteroviruses with IC50 of 1.2 uM against coxsackievirus B3 replication, targets nonstructural protein 2C.




MRL-1237(MRL1237) is a potent and selective inhibitor of the replication of Enteroviruses with EC50 of 1-10 uM, targets the nonstructural 2C protein; inhibits poliovirus-specific RNA synthesis in HeLa cells infected with a wild strain but not with an F164Y mutant.




TTP-8307(TTP8307) is a potent inhibitor of the replication of several Rhinoviruses and Enteroviruses, targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50 of 1.2 uM; 3A mutations V45A, I54F, and H57Y confer resistance to TTP-8307.




AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM; mutations in capsid proteins (G3112A, VP1-Ala224Thr, and G2396A, VP3-Arg227Lys mutations) are resistant to AN-12-H5.




OSW-1 is a natural anti-enterovirus and anti-cancer compound that targets oxysterol-binding protein (OSBP) with Ki of 26 and 54 nM for OSBP and ORP4L, respectively; potently inhibits the replication of enteroviruses with IC50 values in the low nanomolar range; exhibits antiproliferative activity in HCT-116 and HeLa cell lines.




Vapendavir (BTA798) is a novel potent enteroviral capsid binder, inhibits EV71 replication of all isolates with mean EC50 of 0.7 uM; efficiently inhibits the in vitro replication of 21 EV71 strains/isolates that are representative of the different genogroups A, B, and C; Vapendavir (BTA798) is currently under clinical study for the treatment of rhinovirus infections.

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