E3 Ligase Ligand-Linker Conjugate|Inhibitors Agonists Modulators Antagonists|RayStarBio.com

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

Cat. No.	Product Name	CAS No.	Information
GY02952	E3 Ligand-Linker Conjugate 9	1957236-20-2	An E3 ligase ligand-linker conjugate for PROTAC.
GY02839	E3 Ligand-Linker Conjugate 3	1799711-24-2	An E3 ligase ligand-linker conjugate for PROTAC.
GY06947	E3 Ligand-Linker Conjugate 4	2093388-45-3	An E3 ligase ligand-linker conjugate for PROTAC.
GY06946	E3 Ligand-Linker Conjugate 2	2098492-26-1	An E3 ligand- Linker Conjugate for PROTAC.
GY06395	E3 Ligand-Linker Conjugate 8	1957235-74-3	E3 Ligand-Linker Conjugate 8 is an E3 ligase ligand-linker conjugate for PROTAC.
GY06394	E3 Ligand-Linker Conjugate 10	1957236-22-4	E3 Ligand-Linker Conjugate 10 is an E3 ligase ligand-linker conjugate for PROTAC.
GY06391	E3 Ligand-Linker Conjugate 6	2022182-57-4	E3 Ligand-Linker Conjugate 6 is an E3 ligase ligand-linker conjugate for PROTAC.
GY06390	E3 Ligand-Linker Conjugate 7	2022182-59-6	E3 Ligand-Linker Conjugate 7 is an E3 ligase ligand-linker conjugate for PROTAC.
GY06388	E3 Ligand-Linker Conjugate 5	2093388-69-1	E3 Ligand-Linker Conjugate 5 is an E3 ligase ligand-linker conjugate for PROTAC.
GY06387	E3 Ligand-Linker Conjugate 1	2098488-36-7	E3 Ligand-Linker Conjugate 1 is an E3 ligand- Linker Conjugate for PROTAC.

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