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You are here:Home-PROTACs-E3 Ligase Ligand-Linker Conjugate

Request The Product List ofE3 Ligase Ligand-Linker Conjugate E3 Ligase Ligand-Linker Conjugate

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

Cat. No. Product Name CAS No. Information
GY02952

E3 Ligand-Linker Conjugate 9

 		1957236-20-2

An E3 ligase ligand-linker conjugate for PROTAC.
GY02839

E3 Ligand-Linker Conjugate 3

 		1799711-24-2

An E3 ligase ligand-linker conjugate for PROTAC.
GY06947

E3 Ligand-Linker Conjugate 4

 		2093388-45-3

An E3 ligase ligand-linker conjugate for PROTAC.
GY06946

E3 Ligand-Linker Conjugate 2

 		2098492-26-1

An E3 ligand- Linker Conjugate for PROTAC.
GY06395

E3 Ligand-Linker Conjugate 8

 		1957235-74-3

E3 Ligand-Linker Conjugate 8 is an E3 ligase ligand-linker conjugate for PROTAC.
GY06394

E3 Ligand-Linker Conjugate 10

 		1957236-22-4

E3 Ligand-Linker Conjugate 10 is an E3 ligase ligand-linker conjugate for PROTAC.
GY06391

E3 Ligand-Linker Conjugate 6

 		2022182-57-4

E3 Ligand-Linker Conjugate 6 is an E3 ligase ligand-linker conjugate for PROTAC.
GY06390

E3 Ligand-Linker Conjugate 7

 		2022182-59-6

E3 Ligand-Linker Conjugate 7 is an E3 ligase ligand-linker conjugate for PROTAC.
GY06388

E3 Ligand-Linker Conjugate 5

 		2093388-69-1

E3 Ligand-Linker Conjugate 5 is an E3 ligase ligand-linker conjugate for PROTAC.
GY06387

E3 Ligand-Linker Conjugate 1

 		2098488-36-7

E3 Ligand-Linker Conjugate 1 is an E3 ligand- Linker Conjugate for PROTAC.

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