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You are here:Home-PROTACs-E3 Ligase Ligand

Request The Product List ofE3 Ligase Ligand E3 Ligase Ligand

The PROTAC molecule consists of a ligand, which binds an E3 ubiquitin ligase, connected by a linker to another ligand that binds the target protein.

The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.

Cat. No. Product Name CAS No. Information
GY07099

CC-885

1010100-07-8

CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1; The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1; promotes both the in vivo and in vitro ubiquitination of GSPT1 by cereblon and decreases the protein half-life of GSPT1.

GY07096

VHL Ligand 4

1631137-45-5

A VHL ligand for PROTAC.

GY07095

VHL-2

1631137-31-9

A VHL ligand for PROTAC.

GY07094

VH-032

1448188-62-2

VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.

GY07093

VHL Ligand 3

1448189-98-7

A VHL ligand for PROTAC.

GY06948

E3 Ligase Ligand 3

1061605-21-7

An E3 ligase ligand-linker conjugate for PROTAC.

GY10575

PROTAC-VHL-ligand hydrochloride

1448189-80-7

PROTAC-VHL-ligand is a von Hippel–Lindau (VHL) ligand used for the proteolysis targeting chimeras (PROTACs) method, induces target protein degradation.

GY03323

E3 ligase Ligand 2

5054-59-1

An E3 ligase ligand for PROTAC.

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