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The PROTAC molecule consists of a ligand, which binds an E3 ubiquitin ligase, connected by a linker to another ligand that binds the target protein.
The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.
Cat. No. | Product Name | CAS No. | Information |
---|---|---|---|
GY07099 |
CC-885 |
1010100-07-8 | CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1; The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1; promotes both the in vivo and in vitro ubiquitination of GSPT1 by cereblon and decreases the protein half-life of GSPT1. |
GY07096 |
VHL Ligand 4 |
1631137-45-5 | A VHL ligand for PROTAC. |
GY07095 |
VHL-2 |
1631137-31-9 | A VHL ligand for PROTAC. |
GY07094 |
VH-032 |
1448188-62-2 | VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM. |
GY07093 |
VHL Ligand 3 |
1448189-98-7 | A VHL ligand for PROTAC. |
GY06948 |
E3 Ligase Ligand 3 |
1061605-21-7 | An E3 ligase ligand-linker conjugate for PROTAC. |
GY10575 |
PROTAC-VHL-ligand hydrochloride |
1448189-80-7 | PROTAC-VHL-ligand is a von Hippel–Lindau (VHL) ligand used for the proteolysis targeting chimeras (PROTACs) method, induces target protein degradation. |
GY03323 |
E3 ligase Ligand 2 |
5054-59-1 | An E3 ligase ligand for PROTAC. |
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