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Dermatitis is irritation or inflammation of the skin. There are many types of dermatitis. Some, such as diaper rash, are characterized by itchy red skin on a specific area of the body. Others involve blisters or breakouts that resemble acne. Dandruff is considered a mild form of dermatitis that affects the scalp. Because most types of dermatitis have a distinctive appearance, they often can be diagnosed based on a physical exam, although other testing, such as patch testing to determine if a specific allergen is to blame for dermatitis, sometimes is necessary. Treatment for dermatitis depends on the type and includes measures to relieve dry skin, itching, and other symptoms.
Types:
~Allergic contact dermatitis ~Irritant contact dermatitis
~Atopic dermatitis ~Stasis dermatitis
~Diaper dermatitis ~Dyshidrotic dermatitis
~Nummular dermatitis ~ Seborrheic dermatitis
~Autosensitization dermatitis ~Perioral dermatitis
Cat. No. | Product Name | CAS No. | Information |
---|---|---|---|
GY05253 |
PF-04965842 |
1622902-68-4 | PF-04965842 (Abrocitinib, PF04965842) is a potent, selective, orally bioavailable JAK1 inhibitor with IC50 of 29 nM; exhibits good selective inhibition profile for JAK1 versus other JAK family enzymes (IC50=803/>10,000/1250 nM for JAK2/JAK3/TYK2, respectively); demonstrates efficacy in a rat adjuvant-induced arthritis (rAIA) model. |
GY04156 |
Crisaborole |
906673-24-3 | A potent PDE4 inhibitor with IC50 of 0.49 uM; also shows inhibition against PDE1A3, PDE3Cat, and PDE7A1; suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines. |
GY04094 |
AR-7 |
80306-38-3 | Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM; produces an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules in mice after topical application; ameliorates the appearance of atopic dermatitis-like skin lesions in AD models. |
GY04093 |
E6005 |
947620-48-6 | Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM; produces an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules in mice after topical application; ameliorates the appearance of atopic dermatitis-like skin lesions in AD models. |
GY05379 |
Asivatrep |
1005168-10-4 | Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons, does not inhibit or activate other TRP channels such as hTRPV2, hTRPV3, hTRPM8 and hTRPA1; inhibits capsaicin-evoked calcium influx in keratinocytes at sub-micromolar concentrations, blocks capsaicin-induced blood perfusion increase, and the accelerated barrier recovery from tape-stripping-induced barrier damages in hairless mice, also attenuates dermatitis-associated barrier damages in Df and OXZ models. |
GY05065 |
PF 5212372 |
916136-25-9 | PF 5212372 (PLA-950, ZPL-521, ZPL 5212372) is a potent, selective inhibitor of cPLA2 (cytosolic phospholipase A2α) with IC50 of 7 nM; inhibits PGD2 and cysteinyl leukotriene release from anti-IgE-stimulated human lung mast cells with IC50 of 0.29 and 0.45 nM, respectively; inhibits ionomycin-stimulated release of leukotriene B(4), thromboxane A(2), and PGD(2) (IC50 2.6, 2.6, and 4.0 nM, respectively); significantly inhibits AMP-induced contraction of human bronchi. |
GY05058 |
Difamilast |
937782-05-3 | Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM). |
GY06098 |
PF-3893787 |
943057-12-3 | PF-3893787(ZPL-3893787;ZPL-389;PF-03893787) is a potent and selective H4 receptor antagonist with binding Ki of 2.4 nM; has an IC50 of 1.16 nM on human native isolated eosinophils assessing actin polymerisation; exhibits anti-inflammatory activity. |
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