咨询订购

点击这里给我发消息
Welcome to Raystarbio!Focus On Forefront Bioactive Compounds.
Find Your Distributors

Select Your Country or Region

$ USD

You are here:Home-Research Areas-Inflammation/Autoimmune Disease-Dermatitis

Request The Product List ofDermatitis Dermatitis

   Dermatitis is irritation or inflammation of the skin. There are many types of dermatitis. Some, such as diaper rash, are characterized by itchy red skin on a specific area of the body. Others involve blisters or breakouts that resemble acne. Dandruff is considered a mild form of dermatitis that affects the scalp. Because most types of dermatitis have a distinctive appearance, they often can be diagnosed based on a physical exam, although other testing, such as patch testing to determine if a specific allergen is to blame for dermatitis, sometimes is necessary. Treatment for dermatitis depends on the type and includes measures to relieve dry skin, itching, and other symptoms.


  Types:

~Allergic contact dermatitis     ~Irritant contact dermatitis


~Atopic dermatitis                    ~Stasis dermatitis 


~Diaper dermatitis                     ~Dyshidrotic dermatitis

 

~Nummular dermatitis               ~ Seborrheic dermatitis


~Autosensitization dermatitis      ~Perioral dermatitis


Cat. No. Product Name CAS No. Information
GY05253

PF-04965842

1622902-68-4

PF-04965842 (Abrocitinib, PF04965842) is a potent, selective, orally bioavailable JAK1 inhibitor with IC50 of 29 nM; exhibits good selective inhibition profile for JAK1 versus other JAK family enzymes (IC50=803/>10,000/1250 nM for JAK2/JAK3/TYK2, respectively); demonstrates efficacy in a rat adjuvant-induced arthritis (rAIA) model.

GY04156

Crisaborole

906673-24-3

A potent PDE4 inhibitor with IC50 of 0.49 uM; also shows inhibition against PDE1A3, PDE3Cat, and PDE7A1; suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.

GY04094

AR-7

80306-38-3

Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM; produces an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules in mice after topical application; ameliorates the appearance of atopic dermatitis-like skin lesions in AD models.

GY04093

E6005

947620-48-6

Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM; produces an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules in mice after topical application; ameliorates the appearance of atopic dermatitis-like skin lesions in AD models.

GY05379

Asivatrep

1005168-10-4

Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons, does not inhibit or activate other TRP channels such as hTRPV2, hTRPV3, hTRPM8 and hTRPA1; inhibits capsaicin-evoked calcium influx in keratinocytes at sub-micromolar concentrations, blocks capsaicin-induced blood perfusion increase, and the accelerated barrier recovery from tape-stripping-induced barrier damages in hairless mice, also attenuates dermatitis-associated barrier damages in Df and OXZ models.

GY05065

PF 5212372

916136-25-9

PF 5212372 (PLA-950, ZPL-521, ZPL 5212372) is a potent, selective inhibitor of cPLA2 (cytosolic phospholipase A2α) with IC50 of 7 nM; inhibits PGD2 and cysteinyl leukotriene release from anti-IgE-stimulated human lung mast cells with IC50 of 0.29 and 0.45 nM, respectively; inhibits ionomycin-stimulated release of leukotriene B(4), thromboxane A(2), and PGD(2) (IC50 2.6, 2.6, and 4.0 nM, respectively); significantly inhibits AMP-induced contraction of human bronchi.

GY05058

Difamilast

937782-05-3

Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM).

GY06098

PF-3893787

943057-12-3

PF-3893787(ZPL-3893787;ZPL-389;PF-03893787) is a potent and selective H4 receptor antagonist with binding Ki of 2.4 nM; has an IC50 of 1.16 nM on human native isolated eosinophils assessing actin polymerisation; exhibits anti-inflammatory activity.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:
© Copyright 2020 RayStarBio. All Rights Reserved. Products are only for research use