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You are here:Home-Research Areas-Cancer-Chemotherapeutic Agents

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    Chemotherapy is the abbreviation of chemical medicine treatment. It can kill cancer cells by using chemical medicine. Chemotherapy is one of the most effective methods to treat cancer, and it is called the three major treatment methods together with surgery and radiotherapy. Surgery and radiotherapy belong to local treatment, which is only effective for tumors at the treatment site. It is difficult to give full play to the effective treatment for potential metastatic lesions (cancer cells have actually metastasized, but because the current technical means are limited in clinical detection and detection) and cancers with clinical metastasis. Chemotherapy is a means of systemic treatment. No matter what way of Drug Administration (oral, intravenous and body cavity administration, etc.), chemotherapy drugs will spread throughout most organs and tissues with blood circulation. Therefore, chemotherapy is the main treatment for some tumors with general dissemination tendency and those with metastasis.

Cat. No. Product Name CAS No. Information
GY04400

Aprepitant

170729-80-3

A potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM; blocks NK-1 agonist-induced foot tapping response in gerbils and shows antiemetic actions in the ferret against cisplatin challenge; has the potentiation for the treatment of peripheral pain, migraine, chemotherapy-induced emesis, and various psychiatric disorders.

GY02863

Ombrabulin

181816-48-8

A novel combretastatin A-4 derivative and tubulin polymerization inhibitor that strongly stanches tumour blood flows and inhibits growth of tumours developing in various tissues and organ; a vascular-disrupting agent under clinical investigation combined with cisplatin/docetaxel or carboplatin/paclitaxel in patients with advanced solid tumors.

GY02826

Tegafur

17902-23-7

A chemotherapeutic prodrug of 5-flourouracil (5-FU) used in the treatment of cancers; a thymidylate synthase inhibitor.

GY02815

Voreloxin

175414-77-4

A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II; exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively.

GY02640

Sapacitabine

151823-14-2

An orally available, nucleoside analog prodrug of CNDAC that interferes with DNA synthesis by causing single-strand DNA breaks; induces arrest of the cell division cycle at G2 phase, demonstrates potent anti-tumor activity in both blood and solid tumors.

GY02450

Pemetrexed

137281-23-3

A classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively; increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma.

GY02353

Satraplatin

129580-63-8

Satraplatin (BMS-182751, BMY-45594, JM-216) is a platinum-based antineoplastic agent that binds to guanine residues in DNA, inhibits DNA replication and transcription, leads to subsequent apoptosis; shows similar cytotoxicity and pattern of cytotoxicity to cisplatin against human ovarian carcinoma cell lines (IC50=1.7 uM); shows antitumor selectivity far superior to cisplatin, carboplatin, or tetraplatin in vivo; orally active.

GY01972

Amonafide

69408-81-7

A novel topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

GY01945

Cephalomannine

71610-00-9

A taxol derivative with antitumor, antiproliferative properties.

GY01905

Gimeracil

103766-25-2

An inhibitor of dihydropyrimidine dehydrogenase, degrades pyrimidine including 5-fluorouracil in the blood; inhibits homologous recombination.

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