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ML327 is a small molecule that restores E-cadherin expression through regulation of E-cadherin transcription, displays an In-Cell Western EC50 of 1.0 uM; is inactive (>30 uM) against all know epigenetic targets (HDACs, MMPs, Sirtuins, etc.) that increase E-cadherin expression, and clean in a Ricerca ancillary pharmacology panel; possesses favorable physiochemical properties, an excellent dystrophia myotonica protein kinase (DMPK) profile.
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