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You are here:Home-Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-CREB/CBP

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A small-molecule antagonist of CREB-CBP interaction, inhibits the cAMP-dependent activation of cellular genes via CREB; disruptes phospho (Ser-133) CREB binding to CBP KIX domain with Ki of 90 uM, similar Ki for binding of phospho (Ser-133) CREB protein to p300; also interferes with the Myb-KIX interaction in vitro and inhibits Myb activity in vivo.

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