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HLY-78 is an activator of the Wnt/β-catenin signaling pathway that targets the DIX domain of Axin; potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction; acts synergistically with Wnt in the embryonic development of zebrafish and increases the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb, in zebrafish embryos.

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