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You are here:Home-Inhibitors & Agonists-GPCR-Angiotensin Receptor

Request The Product List ofAngiotensin Receptor Angiotensin Receptor

Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Cat. No. Product Name CAS No. Information
GY10293

TD-0212

1073549-10-6

TD-0212 (TD0212) is a potent, orally efficacious, dual AT1 antagonist/Neprilysin (NEP) inhibitor with pKi of 8.9 (AT1) and pIC50 of 9.2 (NEP); produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors in models of renin-dependent and -independent hypertension, does not increase TPE at antihypertensive doses in rat tracheal plasma extravasation (TPE) models.

GY04160

BIBS39

133085-33-3

BIBS-39 is a selective nonpeptide angiotensin II receptor antagonist with Ki of 29 nM and 480 nM for AT1 and AT2 respectively; shows no high affinity for other receptors, shifts the AII concentration-contractile response curves in isolated rabbit aorta with pA2 of 8.14 and a slope of 1.06; shows effective antihypertensives in the model of the renal hypertensive rat.

GY03394

Angiotensin II 5-valine

58-49-1

Angiotensin II 5-valine is an angiotensin II analog that is an agonist of AT1 angiotensin receptor.

GY06194

Losartan

114798-26-4

Losartan (DuP-753) is a selective, competitive angiotensin II receptor type 1 (AT1) antagonist (IC50=20 nM) for treatment of high blood pressure (hypertension).

GY06183

Losartan potassium

124750-99-8

Losartan potassium (DuP-753 potassium) is a selective, competitive angiotensin II receptor type 1 (AT1) antagonist (IC50=20 nM) for treatment of high blood pressure (hypertension).

GY06176

Valsartan

137862-53-4

Valsartan (CGP-48933) is an angiotensin II receptor antagonist for treatment of high blood pressure and heart failure.

GY06173

Candesartan

139481-59-7

Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

GY06171

Olmesartan

144689-24-7

Olmesartan(RNH 6270;CS 088) is an angiotensin II receptor antagonist which has been used for the treatment of high blood pressure.

GY06170

Olmesartan medoxomil

144689-63-4

Olmesartan medoxomil (CS-866) is an angiotensin II receptor antagonist which has been used for the treatment of high blood pressure.

GY06168

Candesartan cilexetil

145040-37-5

Candesartan cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

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