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You are here:Home-Inhibitors & Agonists-Metabolic Enzyme/Protease-Acetylcholinesterase (AChE)

Request The Product List ofAcetylcholinesterase (AChE) Acetylcholinesterase (AChE)

Acetylcholinesterase (AChE or acetylhydrolase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs tocarboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules ofacetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic nerve and ACh is synthetized by combining with acetyl-CoA through the action of choline acetyltransferase.

Cat. No. Product Name CAS No. Information
GY07081

AD-35 phosphate

1531586-64-7

AD-35 phosphate is a donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.

GY06424

Ipidacrine hydrochloride hydrate

118499-70-0

Ipidacrine hydrochloride hydrate is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels; enhances not only choline, but also adrenaline, serotonin, histamine, and oxytocin effects on smooth muscle.

GY06410

AD-35

1531586-58-9

AD-35(AD 35;AD35) is a donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.

GY06409

AD-35 hydrochloride

1531586-62-5

AD-35 hydrochloride is a donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.

GY06378

TAK-802

263248-16-4

TAK-802 (TAK 802;TAK802) is a potent acetylcholinesterase (AChE) inhibitor with IC50 of 1.3 nM; exhibits high selectivity for acetylcholinesterase inhibition over butyrylcholinesterase inhibition; increases rhythmic bladder contractions in Guinea pigs and rats without affecting the basal intravesical pressure.

GY06377

TAK-802 hydrochloride

263248-36-8

TAK-802 hydrochloride is a potent acetylcholinesterase (AChE) inhibitor with IC50 of 1.3 nM; exhibits high selectivity for acetylcholinesterase inhibition over butyrylcholinesterase inhibition; increases rhythmic bladder contractions in Guinea pigs and rats without affecting the basal intravesical pressure.

GY06376

Zanapezil

263248-42-6

Zanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM; ameliorates the passive avoidance deficit induced by diazepam in animal models at 1-3 mg/kg, ameliorates the impairment of DMTP performance induced by scopolamine without affecting the general behavior of the rats.

GY06359

Ipidacrine hydrochloride

90043-86-0

Ipidacrine hydrochloride(Amiridine;NIK 247) is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels; enhances not only choline, but also adrenaline, serotonin, histamine, and oxytocin effects on smooth muscle.

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