Welcome to Raystarbio!Focus On Forefront Bioactive Compounds.
Find Your Distributors

Select Your Country or Region

 $ USD

sales@raystarbio.com
You are here:Home-Inhibitors & Agonists-Metabolic Enzyme/Protease-15-PGDH

Request The Product List of15-PGDH 15-PGDH

15-PGDH (15-Hydroxyprostaglandin dehydrogenase) is a tumor suppressor in breast, colon, liver, lung, and pancreas since decreased expression of this enzyme is associated with increased tumorigenesis. 15-PGDH metabolizes intracellular PGE2 so that this ligand is unable to bind EP receptors, which results in suppression of PGE2 signaling.

The tumor suppressor 15-PGDH is the key enzyme in prostaglandin E2 catabolism and is down-regulated in colorectal cancer (CRC) tissue. Canonical Wnt signaling is frequently elevated in colon cancers and has been shown to down-regulate 15-PGDH expression.

Inhibition of 15-PGDH, a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice. 15-PGDH acts in vivo as a negative regulator of prostaglandin levels and activity, provides a candidate target.

Cat. No. Product Name CAS No. Information
GY04204

SW033291

 		459147-39-8

A potent and selective inhibitor of 15-PGDH with Ki of 0.1 nM, IC50 of 1.5 nM; increases PGE2 levels by 3.5-fold at 500 nM, with EC50 of 75 nM; increases prostaglandin PGE2 levels in bone marrow and other tissues, accelerates hematopoietic recovery in mice receiving a bone marrow transplant; also promotes tissue regeneration in mouse models of colon and liver injury.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:
© Copyright 2020 RayStarBio. All Rights Reserved. Products are only for research use
浙ICP备18012073号-2